Protein phosphatase 1 regulatory subunit 16B (PPP1R16B)

Protein phosphatase 1 regulatory subunit 16B (PPP1R16B) is a membrane-associated protein containing five ankyrin repeats, a protein phosphatase 1-interacting domain, and a CAAX box at its C-terminus. It functions as a regulator of protein phosphatase 1 (PP1), positively regulating pulmonary endothelial cell barrier function and participating in angiogenesis, endothelial cell proliferation, and filopodia extension. PPP1R16B modulates the activity of PP1 by facilitating dephosphorylation events crucial for cellular signaling, especially in vascular tissues, and protects the endothelial barrier against lipopolysaccharide-induced leakage. Synthesis of PPP1R16B is inhibited by transforming growth factor beta-1 (TGF-beta1), identifying it as a downstream target in TGF-beta1 signaling. Multiple isoforms are produced by alternative splicing. Disease association is primarily described with primary ciliary dyskinesia, with possible roles in pulmonary and vascular pathophysiology. No direct drug interactions, biomarker usage, or established safety concerns are currently listed.

Other names

Protein phosphatase 1 regulatory inhibitor subunit 16BPPP1R16BANKRD4KIAA0823TIMAPhTIMAPAnkyrin repeat domain-containing protein 4CAAX box protein TIMAPTGF-beta-inhibited membrane-associated protein