Protein phosphatase 1 regulatory subunit 27 (PPP1R27)

Protein phosphatase 1 regulatory subunit 27 (PPP1R27) is a member of the large family of PP1 regulatory subunits, which determine the substrate specificity, localization, and functional outputs of the ubiquitous serine/threonine protein phosphatase 1 (PP1) enzyme family[1][2]. Regulatory subunits like PPP1R27 do not have catalytic activity themselves, but rather bind PP1 to direct its phosphatase activity toward specific substrates or cellular compartments[1][2][3]. PPP1R27 has also been reported as Dysferlin-interacting protein 1 (DYSFIP1), suggesting a specific role in muscle or membrane repair processes through interaction with the dysferlin protein. The function of PPP1R27 remains less well characterized in the primary literature compared to better-known PP1 regulatory subunits, but by analogy with other members of this family, it is expected to regulate the activity and targeting of PP1 in a tissue- or substrate-specific manner[1]. No drugs, disease links, or biomarker data are currently established for PPP1R27. Notes: - PPP1R27 is a regulatory subunit, not a receptor, enzyme, transporter, or canonical therapeutic target. - The target is correctly named/categorized. - There is insufficient evidence to classify it as a drug target or associate it with known drugs, mechanisms of action, biomarkers, or specific safety concerns. - Its main biological significance appears to be the modulation of PP1 enzyme function and possibly cytoskeletal/membrane activity related to dysferlin interaction[5][6].

Other names

PPP1R27DYSFIP1Dysferlin-interacting protein 1toonin