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Protein phosphatase 1 regulatory subunit 35 (PPP1R35)
- Target
- PPP1R35
- Molecular classification
- Protein phosphatase regulator, Centrosomal protein, Other (regulatory subunit of PP1, not an enzyme itself)
01
Overview
PPP1R35 is a regulatory subunit that interacts with protein phosphatase 1 (PP1), acting as a centrosomal protein required for proper centriole elongation and centriole-to-centrosome conversion. Its loss impairs centriole elongation and reduces centrosome number, highlighting a critical role in cell division and developmental processes. PPP1R35 functions via complex formation with RTTN (Rotatin), another centriolar protein, modulating the recruitment of structural and elongation machinery for centrioles. It harbors a conserved PP1-binding motif, but its centrosomal functions can be independent of direct PP1 interaction. PPP1R35 is enriched in vertebrate cells, and is suggested to play roles in ciliogenesis and centrosome homeostasis.
- Other names
- PPP1R35C7orf47MGC22793protein phosphatase 1 regulatory subunit 35UPF0683 protein C7orf47
02
Mechanism of action
Not applicable; no drugs target this molecule directly. PPP1R35 functions as a scaffolding/regulatory subunit
03
Biological functions
Positive regulation of centriole elongationCentriole-to-centrosome conversionProtein phosphatase inhibitor activityPhosphatase binding (modulates PP1 activity)Facilitates primary cilia assembly
04
Disease associations
None established directly; associated with centriolar and centrosomal dysfunctionsIndirect associations with "Alpha-2-Plasmin Inhibitor Deficiency" and "Mucolipidosis III Gamma" in genetic studies
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