Protein phosphatase 1 regulatory subunit 37 (PPP1R37)

Protein phosphatase 1 regulatory subunit 37 (PPP1R37) is a member of the PPP1R family, a large group of proteins that interact with and regulate the catalytic activity of protein phosphatase 1 (PP1). PPP1R37 is structurally characterized by leucine-rich repeats (LRRC68) and is thought to serve as a targeting or scaffold protein that directs PP1 to specific subcellular locations or substrates. Through its association with PP1, PPP1R37 helps confer substrate specificity and spatial regulation to the enzyme, critical for appropriate dephosphorylation of target proteins during key cellular processes. The regulatory subunits of PP1, including PPP1R37, do not exhibit catalytic activity themselves but are central to the substrate specificity and functional diversity of the PP1 pathway. While PPP1R37 has not been implicated as a direct disease gene or a target of pharmacological agents, it forms part of the intricate regulatory networks governing reversible protein phosphorylation in mammalian cells.

Other names

PPP1R37KIAA1986LRRC68Leucine-rich repeat-containing protein 68

Not applicable; no drugs directly target PPP1R37. PPP1R37 acts by modulating the activity and specificity of protein phosphatase 1 holoenzymes, typically through short linear motifs that mediate the assembly and substrate selection of the holoenzyme complex.