Protein phosphatase 1 regulatory subunit 3E (PPP1R3E)

Protein phosphatase 1 regulatory subunit 3E is a protein encoded by the *PPP1R3E* gene in humans. It acts as a glycogen-targeting subunit for PP1, a critical regulatory enzyme in glycogen metabolism. PPP1R3E enables PP1 to dephosphorylate and activate glycogen synthase, promoting glycogen synthesis. This process is coordinated by the binding of PPP1R3E to PP1 and its localization to glycogen particles. PPP1R3E is part of a family of more than 100 different PP1 regulatory subunits, which confer substrate specificity and functional diversity to the core phosphatase. Dysfunction of related regulatory subunits has been implicated in metabolic and neurological disorders[4][5][3][9]. - *Note*: While PPP1R3E is less studied than some variants (such as PPP1R3D or GM), its core functional role as a PP1 subunit is established in protein and pathway databases[4][5]. There are currently no drugs targeting PPP1R3E, nor is it established as a routine clinical biomarker. Safety concerns are theoretical and similar to other glycogen metabolism regulators.

Other names

PPP1R3EFLJ00089protein phosphatase 1, regulatory (inhibitor) subunit 3E

Not established for drugs, but mechanistically PPP1R3E directs PP1 to the glycogen particle, enabling PP1 to dephosphorylate glycogen synthase and phosphorylase, thus regulating glycogen synthesis and breakdown[4][3][9].