Protein phosphatase 1 regulatory subunit 3G (PPP1R3G)

Protein phosphatase 1 regulatory subunit 3G (PPP1R3G) is a regulatory subunit of protein phosphatase 1 (PP1) that targets PP1 predominantly to glycogen, thereby modulating glycogen metabolism in tissues such as liver and adipose tissue[1][2][6]. PPP1R3G enhances glycogen synthase activity and inhibits glycogen phosphorylase activity, regulating glycogen storage and glucose homeostasis coupled to the fasting-feeding cycle[1][2][6]. In the context of disease, PPP1R3G has been implicated as a diagnostic and prognostic biomarker in various cancers, showing complex associations with tumor immune infiltration, angiogenesis, and inflammation, and may influence cancer progression and therapeutic responses, especially in the tumor microenvironment[2]. Genetic variations or dysregulation of PPP1R3G are also linked to metabolic disorders such as familial hyperinsulinemic hypoglycemia and might play roles in obesity and other metabolic syndromes[1][2]. There are currently no drugs that specifically target PPP1R3G, but its function as a modulator of a major cellular phosphatase and its disease associations make it a candidate of research interest for both metabolic and oncological therapeutic development[2].

Other names

PPP1R3GProtein phosphatase 1, regulatory (inhibitor) subunit 3GPPP1R3AG[4]Putative protein phosphatase 1 regulatory inhibitor subunit 3G[1]

Not established for drugs (as direct targeting drugs are currently unknown) Mechanistically, PPP1R3G modulates activity of protein phosphatase 1, thus indirectly affecting glycogen metabolism, and in the context of cancer, may regulate immune responses and cell death[2]