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Protein phosphatase 1 regulatory subunit 42 (PPP1R42)
- Target
- PPP1R42
- Molecular classification
- Other (Regulatory subunit of protein phosphatase complex)
01
Overview
Protein phosphatase 1 regulatory subunit 42 (PPP1R42) is a protein-coding gene that encodes a positive regulatory subunit of PP1 phosphatase complexes, predominantly expressed in the testis. PPP1R42 modulates PP1 activity and plays an important role in maintaining centrosome integrity during cell division, through interactions with gamma-tubulin and actin-dynein complexes. Although associated with the regulation of cell cycle events and reported linkage to subacute bacterial endocarditis, PPP1R42 is not currently considered a therapeutic target and has no known drug interactions[1][2][6].
- Other names
- PPP1R42LRRC67TLLRTLRRdtrtestis leucine-rich repeatleucine-rich repeat-containing protein 67Leucine rich repeat containing 67
02
Mechanism of action
None known; no drugs target this regulatory subunit directly[1][2][6]
03
Biological functions
Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes, especially in the *testis*Interacts with gamma-tubulin; involved in control of centrosome integrity and separation*Actin binding* and *dynein complex binding*Positive regulation of PP1 activity related to cell division and centrosome dynamics
04
Disease associations
Subacute bacterial endocarditis (reported association)Potential regulatory roles in cell cycle and centrosome integrity, but no established strong disease linkage
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