Protein phosphatase 1 regulatory subunit 9A (PPP1R9A)

Protein phosphatase 1 regulatory subunit 9A (PPP1R9A), also known as neurabin-1, is an actin-binding scaffolding protein that serves as a regulatory subunit of protein phosphatase 1 (PP1) and plays a key role in the organization and reorganization of the neuronal actin cytoskeleton[1][2]. The protein contains a PDZ domain and a sterile alpha motif (SAM), and is primarily expressed in neuronal tissues as well as some embryonic tissues[1]. PPP1R9A controls the formation and maturation of dendritic spines by bundling F-actin and targeting PP1 activity to specific synaptic locations, thereby modulating both structural and functional aspects of excitatory synapses[2]. Mutations and altered expression of PPP1R9A have been implicated in neurodevelopmental conditions, including autism spectrum disorder[1]. No known small-molecule drugs are reported to directly target PPP1R9A, but its critical role as a PP1 regulatory subunit and cytoskeletal scaffold protein places it at the intersection of key signaling and structural processes in neurons[1][2].

Other names

Neurabin-1Neurabin-IKIAA1222FLJ20068NRB1NRBIneural tissue-specific F-actin-binding protein INEB1

Selective targeting and inhibition of protein phosphatase 1 activity at synapses and in association with actin cytoskeleton[1][2]. Modulation of synaptic AMPA receptor targeting and signaling[2].