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Protein phosphatase 1E (PP2C domain containing) (PPM1E)
- Target
- PPM1E
- Molecular classification
- Enzyme, Protein phosphatase, Serine/threonine-protein phosphatase
01
Overview
Protein phosphatase 1E (PP2C domain containing) is a nuclear serine/threonine-protein phosphatase that requires Mg2+ or Mn2+ for activity. It dephosphorylates and inactivates multiple substrates, including the multifunctional Ca2+/calmodulin-dependent protein kinases (such as CAMK4 and CAMK2), PAK, and AMPK, thereby regulating signal transduction events, actin cytoskeleton organization, and cell morphology. Its dysregulation is implicated in disorders such as Mulibrey nanism, osteoblastoma, and possibly cancers. It belongs to the PPM family of phosphatases and its main functional annotation is protein serine/threonine phosphatase activity[1][3][5][6].
- Other names
- CaMKP-NPOPX1Partner of PIX 1KIAA1072PP2CHCa(2+)/calmodulin-dependent protein kinase phosphatase NNuclear calmodulin-dependent protein kinase phosphatase
02
Biological functions
Signal transductionDephosphorylation of protein kinases (e.g., CAMK4, CAMK2, PAK, AMPK)Regulation of actin fiber organization and cell morphology
03
Disease associations
CancerOsteoblastomaMulibrey nanismOther (potential involvement in neurological signaling due to role in synaptic pathways)
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