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Target intelligence / Profile preview
Breast cancer type 1 susceptibility protein (BRCA1)
- Target
- BRCA1
- Molecular classification
- Tumor suppressor, DNA repair protein, E3 ubiquitin ligase, Transcription factor
01
Overview
BRCA1 (Breast Cancer 1) is a tumor suppressor protein crucial for maintaining genomic stability. It participates in DNA repair, cell cycle regulation, transcriptional activation, and chromatin remodeling. Germline mutations in BRCA1 are strongly associated with increased risk for hereditary breast and ovarian cancers. It functions as an E3 ubiquitin ligase via its RING domain, forms stable heterodimers with BARD1, and interacts with PALB2/BRCA2 to orchestrate homologous recombination-based DNA repair.
- Other names
- BRCAIBreast and ovarian cancer susceptibility protein 1RING finger protein 53Protein phosphatase 1F
02
Mechanism of action
N/A - BRCA1 is typically targeted by restoring its function or targeting downstream pathways when it is deficient.
03
Biological functions
DNA repairHomologous recombinationUbiquitinationTranscriptional regulationCell cycle controlGenome stability
04
Disease associations
Breast cancerOvarian cancerFanconi Anemia subtype S (FA-S)Hereditary cancer syndromes
05
Safety considerations
Off-target effects of therapies aimed at restoring BRCA1 function.Development of resistance to therapies targeting downstream pathways in BRCA1-deficient cancers.Potential for increased risk of secondary malignancies with certain therapies.
06
Biomarkers
BRCA1 mutation statusBRCA1 protein expression levelsLoss of heterozygosity (LOH) at the BRCA1 locusBRCA1 methylation status
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