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Target intelligence / Profile preview
Protein Phosphatase 2A (PP2A)
- Target
- PP2A
- Molecular classification
- Enzyme, Serine/threonine protein phosphatase
01
Overview
Protein Phosphatase 2A (PP2A) is a major serine/threonine phosphatase that is highly conserved across eukaryotes and plays essential roles in regulating numerous cellular processes. It regulates cell proliferation, signal transduction, apoptosis, DNA repair, and cytoskeletal organization by dephosphorylating key signaling molecules such as Akt, p53, c-Myc, and β-catenin. It functions as a heterotrimeric holoenzyme composed of three subunits: Catalytic (C), Scaffolding (A), and Regulatory (B). Historically recognized as a tumor suppressor, pharmacological inhibition has shown therapeutic potential in some contexts.
02
Mechanism of action
Modulation of PP2A activity
03
Biological functions
DephosphorylationCell cycleApoptosisSignal transductionCell proliferationCytoskeletal organizationImmune response
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to broad substrate specificityParadoxical effects (tumor suppressor vs. therapeutic target)
06
Interacting drugs
LB100
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