Protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PPP2R2D)

Protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PPP2R2D) is a regulatory subunit of the major serine/threonine phosphatase PP2A. PPP2R2D is part of the B (B55) family of regulatory subunits, which determine substrate specificity and cellular localization of the PP2A holoenzyme. PPP2R2D is expressed ubiquitously in mammalian cells and is involved in key cellular processes such as cell cycle regulation (notably controlling mitosis entry and exit), chromosome segregation, and regulation of apoptosis and signal transduction pathways, including mTOR. Dysregulation or overexpression of PPP2R2D has been implicated in several cancers, notably gastric cancer, where elevated levels may serve as a poor prognostic biomarker. PPP2R2D and its associated PP2A complexes have been noted as potential therapeutic targets, although their broad cellular roles may pose safety concerns regarding potential effects on normal cell proliferation and survival[1][2][3][4].

Other names

PPP2R2DB55deltaB55DMDS026KIAA1541PR55-deltaPP2A subunit B isoform B55-deltaPP2A subunit B isoform PR55-deltaPP2A subunit B isoform R2-deltaPP2A subunit B isoform deltaprotein phosphatase 2 regulatory subunit B, delta

Modulation of protein phosphatase 2A activity alters cell cycle progression and mitotic signaling; Oncogenic action via increased mTOR activation and downstream effects on tumor proliferation and metastasis