Protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C)

Protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C) is a regulatory subunit of the serine/threonine phosphatase PP2A enzyme complex. PPP2R2C encodes the gamma isoform of the B55 (PR55) family. PP2A is a key negative regulator of cell growth and division, controlling phosphorylation states of many critical signaling molecules. The B regulatory subunits, including PPP2R2C, influence both substrate specificity and subcellular localization of PP2A holoenzymes. While PPP2R2C and its family members are structurally similar, they are expressed in distinct tissues and developmental stages, particularly modulating neuronal differentiation and signal transduction pathways such as the MAPK cascade. PPP2R2C and the PP2A complex are implicated in tumor suppression and have roles in neurodegenerative diseases, but as of now, there are no therapies that specifically target PPP2R2C in clinical practice; modulating PP2A broadly remains a frontier of drug development with substantial challenges in selectivity and safety[1][3][4].

Other names

PP2A subunit B gammaPR55B gammaB55gammaPR52IMYPNOIMYPNO1MGC33570PR55GPP2A regulatory subunit B gammaPhosphoprotein phosphatase 2A BR gamma regulatory chain

Drugs that modulate PP2A generally act by activating or inhibiting phosphatase activity, leading to altered dephosphorylation of oncogenic or neurodegenerative signaling pathways[1]. Selective modulation of substrate specificity or localization via regulatory B subunits (such as PPP2R2C) is a potential future strategy but currently lacks approved agents.