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Target intelligence / Profile preview
Protein phosphatase 2A subunit B55alpha (None)
- Target
- None
- Molecular classification
- Enzyme, Protein Phosphatase, Regulatory Subunit
01
Overview
Protein phosphatase 2A subunit B55alpha (PP2A-B55α) is a regulatory subunit of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme. PP2A is a major cellular phosphatase involved in the regulation of numerous signaling pathways, cell cycle progression, DNA repair, metabolism, and apoptosis. The B55α isoform shows broad tissue expression and plays critical roles in cell cycle regulation, DNA damage response, and metabolic adaptation by directing PP2A activity toward specific substrates.
- Other names
- PP2A-B55αPPP2R2A protein
02
Mechanism of action
Not applicable; regulatory subunit modulates PP2A enzyme activity
03
Biological functions
Cell cycle regulationDNA damage responseMetabolic adaptationRegulation of ERK/MAPK pathwayRegulation of PI3K/AKT pathway
04
Disease associations
CancerDevelopmental disorders
05
Safety considerations
Dysregulation can lead to genomic instabilityPotential impact on oocyte meiosis and early embryonic development
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