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Target intelligence / Profile preview
Protein phosphatase 2C (PP2C)
- Target
- PP2C
- Molecular classification
- Enzyme, Serine/threonine protein phosphatase, Metal-dependent protein phosphatase, PPM family
01
Overview
Protein phosphatase}
- Other names
- PP2CPPM familyMetal-dependent protein phosphataseWild-type p53-induced phosphatase 1Wip1PPM1DPPM1APPM1BPPM1EPPM1FPPM1G
02
Mechanism of action
Inhibition of phosphatase activity to prevent the dephosphorylation of key signaling proteins such as p53, Chk2, and p38 MAPK, thereby restoring stress-induced pathways and promoting apoptosis or cell cycle arrest in diseased cells [1, 11].
03
Biological functions
Signal transductionCell cycle regulationApoptosisDNA damage responseStress signalingMetabolismImmune response
04
Disease associations
CancerInflammationNeurodegenerative diseaseDiabetesInfection
05
Safety considerations
Potential for off-target effects due to the large number of PP2C isoforms [4]Impairment of normal cellular stress responses [1]Potential for promoting inflammatory responses [5]Toxicity in tissues with high basal PP2C activity [11]
06
Interacting drugs
GSK2830371
4 more in the full profile.
07
Biomarkers
PPM1D gene amplification [3, 11]PPM1D mRNA overexpression [8]TP53 mutation status [11]Phospho-Chk2 levels [8]p21 expression [11]
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