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Protein Phosphatase 3 Catalytic Subunit Alpha (PPP3CA)
- Target
- PPP3CA
- Molecular classification
- Enzyme, Protein Phosphatase, Serine/Threonine Phosphatase, Calcineurin
01
Overview
Protein phosphatase 3 catalytic subunit alpha, also known as PPP3CA or calcineurin A alpha, is a calcium-dependent, calmodulin-stimulated serine/threonine protein phosphatase. It plays an essential role in the transduction of intracellular Ca²⁺-mediated signals and is a key component of the calcineurin complex. It catalyzes the removal of phosphate groups from serine and threonine residues in proteins. Requires both calcium ions and calmodulin for activation. Involved in several cellular processes including calcineurin-NFAT signaling cascade and regulation of gene expression. Mutations or dysregulation are associated with several diseases.
- Other names
- Calcineurin A alphaSerine/threonine-protein phosphatase 2B catalytic subunit alpha isoformSer/Thr-protein phosphatase PP2B-Aalpha
02
Mechanism of action
Inhibition of phosphatase activity.
03
Biological functions
Signal transductionPeptidyl-serine dephosphorylationResponse to calcium ionRegulation of gene expressionCalcineurin-NFAT signaling cascade
04
Disease associations
ArthrogryposisCleft PalateCraniosynostosisDevelopmental And Epileptic Encephalopathy 91Focal Segmental GlomerulosclerosisSchizophrenia
05
Biomarkers
Focal Segmental GlomerulosclerosisSchizophrenia
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