Protein phosphatase 3 catalytic subunit beta (PPP3CB)

Protein phosphatase 3 catalytic subunit beta (PPP3CB), also known as calcineurin A beta, is a calcium-dependent, calmodulin-stimulated serine/threonine phosphatase that is essential for intracellular Ca²⁺-mediated signal transduction[1][3]. It dephosphorylates and regulates several downstream substrates, including transcription factors such as NFAT and ELK1, influencing gene expression, lysosome biogenesis, and cell signaling. PPP3CB forms the catalytic core of the calcineurin complex, plays roles in the immune response, neural signaling, and muscle physiology, and is implicated in cardiovascular, renal, and neuropsychiatric diseases. It is directly targeted by immunosuppressant drugs such as cyclosporin A and tacrolimus[1][3][7].

Other names

Calcineurin A betaProtein phosphatase 2B catalytic subunit beta isoformCalmodulin-dependent calcineurin A subunit beta isoformCNA betaCalcineurin A2CALNA2CALNBCNA2PP2BbetaProtein phosphatase from PCR fragment H32Serine/threonine-protein phosphatase 2B catalytic subunit beta isoformCAM-PRP catalytic subunitProtein phosphatase 3, catalytic subunit, beta isoform

Inhibition of calcineurin phosphatase activity (both cyclosporin A and tacrolimus act by forming complexes with immunophilins, which then inhibit calcineurin, suppressing dephosphorylation and activation of NFAT transcription factors)