Protein phosphatase 3 regulatory subunit B alpha (PPP3R1)

Protein phosphatase 3 regulatory subunit B alpha (PPP3R1) is the regulatory subunit of the enzyme calcineurin, a calcium-dependent and calmodulin-stimulated protein phosphatase. PPP3R1 confers calcium sensitivity to the catalytic subunit, forming a functional phosphatase complex involved in various signaling pathways, including the calcineurin-NFAT signaling cascade important for immune, cardiac, and neural processes. Mutations or variants in PPP3R1 are implicated in diseases such as Alzheimer's disease and dilated cardiomyopathy[1][2][3][5].

Other names

Calcineurin subunit B type 1Protein phosphatase 2B regulatory subunit 1CNA2CNBCALNB1CNB1Protein phosphatase 3 regulatory subunit B alpha isoform 1Calcineurin B, type I (19kDa)Protein phosphatase 2B regulatory subunit B alpha

Inhibition of calcineurin activity (via immunosuppressant drugs such as cyclosporin A and tacrolimus, which target the calcineurin complex containing PPP3R1)