Protein phosphatase 4 regulatory subunit 3B (PPP4R3B)

Protein phosphatase 4 regulatory subunit 3B (PPP4R3B) is a regulatory subunit of the serine/threonine-protein phosphatase 4 (PP4) complex[5][4], which participates in the regulation of cellular protein dephosphorylation processes. PPP4R3B forms heterotrimeric complexes with PP4C (the catalytic subunit) and other regulatory subunits (such as PP4R2)[3]. It is involved in the regulation of double-strand break repair and DNA damage response—critical for maintaining genomic stability—by influencing the activity and substrate specificity of the PP4 phosphatase complex[4][1][3]. PPP4R3B localizes to the nucleus, centrosome, and chromatin[4][5]. While gene-disease association data link PPP4R3B to several inherited conditions (such as sarcosinemia and intracranial abscess), it is not currently known as a direct drug target nor are there any drugs with established mechanisms acting upon it[4]. PPP4R3B, as part of the PP4 complex, plays a crucial biological function in response to DNA damage, and its dysregulation can have significant effects on cell cycle, DNA repair, and possibly tumorigenesis[3][4].

Other names

SMEK2KIAA1387PSY2FLFL2FLJ31474SMEK homolog 2suppressor of mek1smk1