Protein phosphatase 4 regulatory subunit 3C (PPP4R3C)

Protein phosphatase 4 regulatory subunit 3C (PPP4R3C) is a non-catalytic regulatory protein that forms part of the serine/threonine-protein phosphatase 4 complex. It is predicted to act as an **activator** of protein phosphatase activity, facilitating the function of the catalytic subunit PPP4C. PPP4R3C has been implicated in the regulation of DNA damage response, particularly double-strand break repair. While its precise physiological and pathological roles are still being characterized, PPP4R3C does not act as a direct therapeutic target, enzyme, receptor, or transporter. Instead, it modulates the functions of the protein phosphatase 4 complex within the nucleoplasm[1][2][3][4][6][7].\n\n**Notes:** \n- This gene is sometimes annotated as a pseudogene and is not considered a direct drug target. There are currently no known drugs, disease associations, or safety concerns specifically linked to PPP4R3C[6][3][4][7].\n- Some aliases (such as "suppressor of mek1 pseudogene") refer to potential pseudogene status but sequence analysis and functional annotation indicate a protein-coding regulatory subunit in mammals[3][4][6].

Other names

FLJ32867FLFL3Psmk1SMEK3PPPP4R3CPSMEK homolog 3Putative SMEK homolog 3suppressor of mek1 pseudogeneSerine/threonine-protein phosphatase 4 regulatory subunit 3C pseudogene