Protein phosphatase 6 regulatory subunit 2 pseudogene

The "protein phosphatase 6, regulatory subunit 2 pseudogene" refers to a genomic region similar to the protein-coding PPP6R2 gene, but lacking the ability to encode a functional protein. Pseudogenes like this are generally not considered therapeutic targets and do not have demonstrated roles in disease or drug interaction. In contrast, the active PPP6R2 gene encodes a regulatory subunit of protein phosphatase 6, involved in cell division and signal transduction, and its loss of function is associated with spindle formation defects and disease such as Charcot-Marie-Tooth. The correct therapeutic target is Protein phosphatase 6 regulatory subunit 2 (PPP6R2), not the pseudogene. The pseudogene itself is not used as a therapeutic target, nor is it known to have biological or disease roles. The use of "pseudogene" in the name makes this target incorrect from the perspective of therapeutic relevance. If structured/functional target information is required, results should be mapped to the active PPP6R2 gene, not the pseudogene.

Other names

PPP6R2 pseudogene (not the same as the active gene PPP6R2)ENSG00000267324 (Ensembl ID)