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Protein Phosphatase Inhibitor 1 (I-1)
- Target
- I-1
- Molecular classification
- Regulatory Protein, Enzyme Inhibitor
01
Overview
Protein phosphatase inhibitor 1 (I-1) is a regulatory protein and a potent inhibitor of protein phosphatase 1 (PP1), a serine/threonine-specific phosphatase involved in various cellular processes. I-1 is activated by phosphorylation, primarily at Thr35 by PKA, which enables it to bind to PP1 and block its activity. It plays a critical role in regulating cardiac physiology and is implicated in heart failure pathogenesis.
- Other names
- IPP-1
02
Mechanism of action
Inhibition of protein phosphatase 1 (PP1) activity by binding to the active site when phosphorylated, preventing substrate access.
03
Biological functions
Regulation of protein phosphatase 1 (PP1) activityRegulation of glycogen metabolismModulation of Ca²⁺ cyclingRegulation of muscle contractilityIntegration of neurohormonal signalsSignal transduction
04
Disease associations
Heart failureCardiac dysfunction
05
Safety considerations
Dysregulation or altered expression/phosphorylation status can lead to heart failure.
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