Protein phosphatase methylesterase 1 (PPME1)

Protein phosphatase methylesterase 1 (PPME1) is an enzyme that demethylates proteins—including the catalytic subunit of protein phosphatase 2A (PP2A)—thereby regulating PP2A activity, localization, and function. This demethylation modulates several key signaling pathways, such as the ERK pathway, and is implicated in the regulation of cell proliferation, apoptosis, and tumor progression. PME-1 is highly conserved across eukaryotes and possesses a lipase-like catalytic motif with a serine residue essential for its activity. Elevated PME-1 expression has been linked to various human cancers, with evidence of either oncogenic or tumor suppressor roles depending on the tumor context. PME-1 is considered a therapeutically relevant enzyme, but as of now, no therapies directly target it in clinical settings.

Other names

PME1PME-1PP2593PRO0750ABDH19Testicular secretory protein Li 39

Okadaic acid: inhibits PME-1 activity, thereby preventing demethylation of PP2A subunit C. Modulators of PME-1 would theoretically alter PP2A activity by affecting the methylation state of its catalytic subunit