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Protein phosphatase Slingshot homolog 1 (SSH1)
- Target
- SSH1
- Molecular classification
- Enzyme, Protein phosphatase
01
Overview
Protein phosphatase Slingshot homolog 1 (SSH1) is a human enzyme that belongs to the slingshot phosphatase family and plays a critical role in regulating actin filament dynamics by dephosphorylating and activating cofilin, an actin-binding and depolymerizing factor[1][2][3][4][6][7]. SSH1 thereby facilitates actin filament turnover, which is essential for cellular movement, shape, and signal transduction. Dysregulation of SSH1 or improper control of actin dynamics is associated with various pathological states, including cancer metastasis and genetic diseases involving abnormal cell motility[1][2][3].
- Other names
- SSH1SSH-like protein 1Slingshot protein phosphatase 1SSH1_HUMAN
02
Mechanism of action
Inhibition or modulation of SSH1 phosphatase activity to alter actin dynamics
03
Biological functions
Regulation of actin filament dynamicsSignal transductionCell movementCytoskeleton organization
04
Disease associations
CancerNoonan syndrome 11PorokeratosisOther diseases linked to cytoskeletal regulation
05
Safety considerations
Potential disruption of cytoskeletal organization and cell motility with therapeutic inhibitionEffects on normal tissue repair and cell movement
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