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Target intelligence / Profile preview
Protein S-glutathionylation (PSSG)
- Target
- PSSG
- Molecular classification
- Post-translational modification, Redox modification
01
Overview
Protein S-glutathionylation is a reversible post-translational modification involving the covalent attachment of glutathione (GSH) to cysteine residues in proteins. This modification regulates protein structure, activity, and interactions, playing a critical role in redox signaling and protection against irreversible cysteine oxidation. Dysregulation is implicated in various diseases including cancer, cardiovascular dysfunction, and neurodegeneration.
- Other names
- S-glutathionylationProtein glutathionylationGlutathionylation
02
Mechanism of action
Thiol-disulfide exchange; enzymatic catalysis altering protein function
03
Biological functions
Redox regulationProtein structure modulationProtein activity regulationCell signalingProtection from irreversible oxidation
04
Disease associations
Cancer chemoresistanceFibrosisCardiovascular dysfunctionNeurodegenerationInflammatory responsesMetabolic disordersNonalcoholic fatty liver disease
05
Safety considerations
Reversibility/instability under experimental conditionsComplexity of redox signaling networks
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