Protein sel-1 homolog 2 (SEL1L2)

SEL1L2 is an adaptor protein that participates in the endoplasmic reticulum-associated degradation (ERAD) pathway by linking the E3 ubiquitin ligase SYVN1 (HRD1) complex to misfolded cargo proteins destined for proteasomal degradation[1][3][5]. It is evolutionarily related to SEL1L and shares structural features, but SEL1L2 is less well characterized, with its specific protein-protein interactions, tissue distribution, and functional importance remaining subjects for future research[1][3][5]. The ERAD pathway regulates ER protein quality, contributing to cellular homeostasis and response to stress; in this machinery, SEL1L2 is thought to help scaffold the degradation process but has not been directly linked to disease pathology or targeted therapies[1][2].

Other names

SEL1L2C20orf50Sel-1L2DKFZp434C1826suppressor of lin-12-like protein 2protein sel-1 homolog 2SEL1L2 adaptor subunit of ERAD E3 ligasesel-1 suppressor of lin-12-like 2

Not applicable; drugs do not directly target SEL1L2. General ERAD modulation occurs through E3 ligase inhibition or proteasome inhibition[2][4].