Protein sel-1 homolog 3 (SEL1L3)

Protein sel-1 homolog 3 (SEL1L3) is a human transmembrane protein encoded by the SEL1L3 gene and is part of the SEL1-like family[3][5]. Its exact physiological function is not well established, though it shares homology with SEL1L, which is a key component of the endoplasmic reticulum–associated degradation (ERAD) system that manages misfolded proteins[2]. SEL1L3 mRNA is broadly expressed in tissues, with particularly notable cytoplasmic expression in the gastrointestinal tract[9]. Recent research has identified hyper-N-glycosylated SEL1L3 as an auto-antigen in a subset of primary vitreoretinal lymphoma (PVRL): in these patients, SEL1L3 is recognized by the B-cell receptor (BCR), triggers BCR-dependent cell signaling, and may drive proliferation of malignant B-cells[4]. However, there are no established drugs targeting SEL1L3, no mechanism of drug action, and it is not currently classified as a standard druggable therapeutic target or receptor. Its involvement in disease remains an active area of research, with potential roles noted in cancer, prion diseases, and possibly other disease contexts as revealed by gene expression studies[2][3][4][8][10].

Other names

SEL1L3KIAA0746Sel-1L3Suppressor of lin-12-like protein 3sel-1 suppressor of lin-12-like 3protein sel-1 homolog 3

Not established; no therapeutics reported to directly target SEL1L3