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Target intelligence / Profile preview
Protein-serine O-palmitoleoyltransferase porcupine (PORCN)
- Target
- PORCN
- Molecular classification
- Enzyme, Membrane-bound acyltransferase, Porcupine subfamily
01
Overview
PORCN (Protein-serine O-palmitoleoyltransferase porcupine) is a multi-transmembrane enzyme located in the endoplasmic reticulum. It functions as a key regulator of the Wnt signaling pathway by mediating the post-translational attachment of palmitoleate, a 16-carbon monounsaturated fatty acid, to Wnt proteins. This lipid modification is essential for efficient binding of Wnt ligands to their frizzled receptors and subsequent signal transduction. Aberrant activation or dysregulation may contribute to cancer development. Mutations in PORCN cause focal dermal hypoplasia (Goltz syndrome).
- Other names
- PORCPPNMG61DHOFFODH
02
Mechanism of action
Inhibition of WNT palmitoleoylation
03
Biological functions
WNT ligand palmitoleoylationRegulation of canonical and non-canonical WNT signalingEmbryonic development
04
Disease associations
Focal dermal hypoplasia/Goltz syndromeCancer
05
Safety considerations
Wnt signaling is critical for development and tissue homeostasis, therefore broad inhibition may have significant safety liabilities
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