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Protein-serine-threonine kinase
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase
01
Overview
Protein-serine-threonine kinases are a large group of enzymes that catalyze the transfer of a phosphate group from ATP to serine or threonine residues in protein substrates. This post-translational modification regulates protein function and cellular signaling pathways, influencing activity, stability, localization, and interactions. They play fundamental roles in controlling cell growth, differentiation, metabolism, apoptosis, and synaptic plasticity. Dysregulation is implicated in diseases like cancer, neurodegeneration, and metabolic syndromes, making them major therapeutic targets.
- Other names
- ser/thr-protein kinaseSTKser-thr kinase
02
Mechanism of action
Inhibition of kinase activity, preventing phosphorylation of target proteins.
03
Biological functions
Signal transductionCell growthCell differentiationMetabolismApoptosisSynaptic plasticityCell cycle regulation
04
Disease associations
CancerNeurodegenerative disordersMetabolic syndromes
05
Safety considerations
Off-target effects due to the large number of kinases in the human genome.Development of resistance through mutations in the kinase domain.
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