Protein strawberry notch homolog 2 (SBNO2)

Protein strawberry notch homolog 2 (SBNO2) is a nuclear transcriptional regulator found in humans and other mammals, encoded by the SBNO2 gene. It is part of the DExD/H-box helicase family, with presumed ATP-dependent RNA helicase activity. SBNO2 acts as a feedback repressor for interleukin-6 (IL-6)-driven inflammatory gene expression, particularly in astrocytes and immune cells, thereby restraining excessive inflammation and neurodegeneration[1][3][4]. The protein also plays a role in bone homeostasis by regulating osteoclast fusion, modulates the activity of transcription factors such as NF-κB and STATs, and is upregulated in response to inflammatory cytokines (IL-6, IL-10, TNF-α, lipopolysaccharide)[1][3][4][5]. Variants and methylation of the SBNO2 locus are associated with disease susceptibility in Crohn’s disease and alterations in bone density[4][5]. SBNO2’s biological contribution appears most significant in pathological or stress conditions rather than during physiological homeostasis[3][4]. To date, no drugs specifically target SBNO2, but its role in negative feedback control of inflammation—especially in the CNS and gastrointestinal tract—makes it a potential candidate for future therapeutic development.

Other names

SBNO2SNOKIAA0963STNOFLJ00173StnoSnoprotein strawberry notch homolog 2

Drugs impacting SBNO2 would generally act via modulation of transcription factors (e.g., NF-κB, STAT3), cytokine signalling (IL-6, IL-10), or chromatin accessibility[3][4][5].