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Protein Synthesis Elongation
- Molecular classification
- Cellular Process
01
Overview
The protein synthesis elongation step is essential for translating genetic information into functional proteins. It involves repeated cycles where charged tRNAs deliver specific amino acids to a growing peptide chain within the ribosome, driven by precise molecular recognition events and powered by GTP hydrolysis through specialized elongation factors. This process continues until translation reaches a stop signal on mRNA, resulting in complete polypeptides ready for folding into active proteins.
- Other names
- Translation ElongationPolypeptide Chain Elongation
02
Mechanism of action
Varies depending on the specific inhibitor; generally involves disrupting ribosome function or tRNA interaction.
03
Biological functions
Protein biosynthesismRNA translation
04
Disease associations
Viral replication (host protein synthesis hijacking)Cancer (dysregulation of protein synthesis)
05
Safety considerations
Off-target effects on host cell protein synthesisDrug resistance
06
Interacting drugs
Tetracycline (inhibits aa-tRNA binding to the A site)
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