Protein Synthesis in Plasmodium

Protein synthesis in Plasmodium, the causative agent of malaria, is a fundamental process essential for parasite survival. It involves translating genetic information into proteins using ribosomes and associated factors. Unique features compared to human protein synthesis make it an attractive antimalarial drug target. The process is regulated at multiple levels, including global and mRNA-specific mechanisms. Components such as ribosomes and aminoacyl-tRNA synthetases are validated drug targets. Drugs like doxycycline inhibit translation, and novel compounds selectively inhibit Plasmodium protein synthesis.

Other names

Plasmodium Protein SynthesisPlasmodium translational machinery

Inhibition of ribosomal function; Inhibition of aminoacyl-tRNA synthetases; Disruption of elongation factors