Protein synthesis machinery via Pseudomonas exotoxin-mediated inhibition

The cellular process of protein synthesis that is specifically disrupted by the action of Pseudomonas Exotoxin A (PE), a potent bacterial toxin produced by *Pseudomonas aeruginosa*. PE exerts its cytotoxic effect by irreversibly inhibiting eukaryotic protein synthesis, ultimately leading to cell death. PE enters target cells through receptor-mediated endocytosis, undergoes intracellular trafficking to the ER, translocates to the cytosol, and catalyzes ADP-ribosylation of elongation factor 2 (EF-2), an essential component for ribosomal translocation during mRNA translation. This modification inactivates EF-2, halting protein synthesis and triggering cell death. While PE itself is not a therapeutic target, the process of inhibiting protein synthesis by PE is relevant in the context of understanding bacterial pathogenesis and developing targeted therapies that exploit this mechanism.

Other names

Pseudomonas Exotoxin A mediated protein synthesis inhibitionPE-mediated protein synthesis inhibitionElongation Factor 2 ADP-ribosylation by Pseudomonas Exotoxin A

ADP-ribosylation and inactivation of Elongation Factor 2 (EF-2)