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Protein Sulfhydryl Group (PSH)

Target: PSH
Molecular classification: Chemical Group, Amino Acid Side Chain

Overview

A protein sulfhydryl group refers to the functional group –SH (also called a thiol) present in proteins, primarily as part of the amino acid cysteine. It plays a crucial role in disulfide bond formation, protein structure stabilization, redox reactions, and enzyme regulation. Protein sulfhydryls (PSH) and disulfides (PSSP) are dynamically involved in aggregation processes via thiol/disulfide exchange reactions. Modifying these groups affects platelet activation by altering integrin conformations.

Other names: Thiol group in proteinsProtein thiolCysteine sulfhydryl-SH group in proteins

Biological functions

Disulfide bond formationRedox reactionsEnzyme regulationProtein structure stabilizationPlatelet aggregation

Disease associations

Oxidative stress-related diseasesCardiovascular disease (platelet function)Cancer (redox signaling)

Safety considerations

Non-specific targeting can lead to off-target effectsRedox imbalance

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