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Protein Thiol Groups (SH groups)
- Target
- SH groups
- Molecular classification
- Amino acid side chain, Functional group
01
Overview
Protein thiol groups, primarily from cysteine residues, are highly reactive functional groups that play crucial roles in protein structure, function, and regulation. They are involved in disulfide bond formation, redox regulation, catalysis, and metal binding. Disruption of thiol group function can lead to various diseases, including neurodegenerative disorders and heavy metal poisoning.
- Other names
- Sulfhydryl groupsCysteine thiol groupsProtein -SH groups
02
Mechanism of action
Varies depending on the drug; some interact directly with thiol groups.
03
Biological functions
Disulfide bond formationRedox regulationCatalysisMetal bindingProtein foldingProtein stability
04
Disease associations
Neurodegenerative diseasesHeavy metal poisoningOxidative stress related diseases
05
Safety considerations
Off-target binding of drugs to thiol groupsToxicity of heavy metals binding to thiol groups
06
Interacting drugs
6-Mercaptopurine
3 more in the full profile.
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