Protein transport protein Sec23A (SEC23A)

Protein transport protein Sec23A (SEC23A) is a core component of the coat protein complex II (COPII) that facilitates the formation of transport vesicles from the endoplasmic reticulum (ER), enabling the trafficking of newly synthesized proteins and lipids to the Golgi apparatus for secretion or further modification[3][1]. SEC23A acts as a GTPase-activating protein within the COPII inner coat, working in complex with SEC24 and interacting with other coat subunits such as SAR1 and SEC31[1][3]. The protein plays critical roles in the selection of cargo for ER exit, and its function is tightly linked to general secretion processes and autophagy pathways, including regulation by phosphorylation events[1]. Mutations in SEC23A are associated with cranio-lenticulo-sutural dysplasia and other congenital disorders, and its dysregulation is implicated in cancer—where low SEC23A levels are linked to poorer clinical outcomes[1][3]. SEC23A is indispensable for embryonic development and secretory tissue viability, highlighting its therapeutic and pathological relevance[1].

Other names

SEC23AhSec23ASEC23 homolog ACOPII coat complex componentSec23 homolog ACLSDprotein transport protein Sec23ASEC23-related protein A