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Target intelligence / Profile preview
Protein-Tyrosine Kinase (PTK)
- Target
- PTK
- Molecular classification
- Enzyme, Kinase, Receptor Protein Tyrosine Kinase, Nonreceptor Protein Tyrosine Kinase
01
Overview
Protein-tyrosine kinases (PTKs) are enzymes that catalyze the transfer of a phosphate group from ATP to tyrosine residues of specific protein substrates. This phosphorylation event is a key regulatory mechanism in cellular signaling, affecting protein function, localization, and interactions. Dysregulation or mutation of PTK genes can lead to aberrant signaling implicated in cancer development/progression as well as other diseases such as diabetes and immune disorders.
- Other names
- Tyrosine KinaseProtein Tyrosine KinaseTyrosine Protein Kinase
02
Mechanism of action
Catalyzes the transfer of a phosphate group from ATP to tyrosine residues on target proteins, modulating their activity and downstream signaling.
03
Biological functions
Signal transductionCell divisionCell differentiationCell growthCell migrationMetabolismApoptosisImmune responseNeural developmentCell signaling
04
Disease associations
CancerDiabetesImmune disordersEmbryogenesis disorders
05
Safety considerations
Off-target effectsDrug resistanceDevelopment of secondary malignancies
06
Interacting drugs
EGFR inhibitors
2 more in the full profile.
07
Biomarkers
EGFR mutationsBCR-ABL fusion protein
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