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Target intelligence / Profile preview
Protein Tyrosine Phosphatase Non-Receptor Type 11 (SHP2)
- Target
- SHP2
- Molecular classification
- Enzyme, Protein Tyrosine Phosphatase
01
Overview
SHP2 is a ubiquitously expressed non-receptor protein tyrosine phosphatase that plays a central role in cell signaling. It acts as an intracellular signal transducer and is involved in the regulation of several key cellular processes including cell growth, differentiation, mitotic cycle progression, and oncogenic transformation. SHP2 positively modulates the RAS/MAPK signaling pathway and negatively regulates the PI3K/AKT pathway. Mutations or dysregulation of *PTPN11* are implicated in several diseases, including Noonan syndrome and various cancers. SHP2 has emerged as an important drug target, particularly for solid tumors, and allosteric inhibitors are under clinical investigation.
- Other names
- PTPN11PTP-1DPTP-2CSrc homology region 2 domain-containing phosphatase-2
02
Mechanism of action
Allosteric inhibition of SHP2 regulatory mechanism
03
Biological functions
Signal transductionCell growthCell differentiationMitotic cycle progressionOncogenic transformationRegulation of RAS/MAPK signaling pathwayRegulation of PI3K/AKT pathwayTranscription regulationCell migrationApoptosisEmbryonic developmentBone formation
04
Disease associations
Noonan syndromeLEOPARD syndromeJuvenile myelomonocytic leukemiaAcute myeloid leukemiaSolid tumorsCancer
05
Safety considerations
Therapy resistanceImmune escape mechanismsTumor microenvironment modulation
06
Interacting drugs
SHP2 inhibitors (Allosteric inhibitors)
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