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Target intelligence / Profile preview
Protein Tyrosine Phosphatase Non-Receptor Type 6 (SHP-1)
- Target
- SHP-1
- Molecular classification
- Enzyme, Protein Tyrosine Phosphatase, Non-receptor protein tyrosine phosphatases
01
Overview
SHP-1 is a protein tyrosine phosphatase that acts as a negative regulator in multiple signaling pathways within hematopoietic cells, dephosphorylating phospho-proteins involved in immune cell signaling. It functions as a tumor suppressor during tumor progression due to its ability to inhibit pro-oncogenic signals like STAT3 activation. Mutations or altered expression patterns are associated with autoimmune diseases and various cancers.
- Other names
- PTPN6Src homology region 2 domain-containing phosphatase-1
02
Mechanism of action
Activation of SHP-1 phosphatase activity
03
Biological functions
Signal transductionImmune responseNegative regulation of cytokine productionTumor suppressionRegulation of JAK/STAT pathway activitySuppression of inflammatory responses
04
Disease associations
Autoimmune diseasesCancerInflammation
05
Interacting drugs
Regorafenib
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