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Target intelligence / Profile preview
Protein Tyrosine Phosphatase Receptor Type C (CD45)
- Target
- CD45
- Molecular classification
- Enzyme, Receptor, Protein Tyrosine Phosphatase
01
Overview
CD45 (Protein Tyrosine Phosphatase Receptor Type C), also known as the leukocyte common antigen, is a transmembrane protein tyrosine phosphatase expressed on all nucleated hematopoietic cells. It plays a crucial role in regulating immune cell signaling and activation, particularly in T and B lymphocytes, by modulating the activity of Src family kinases and other signaling molecules within the TCR/BCR complexes. Aberrant expression or mutations are implicated in immunodeficiencies and hematologic malignancies, making it a potential therapeutic target.
- Other names
- Leukocyte common antigenLCAPTPRC
02
Mechanism of action
Dephosphorylation of target proteins, modulation of kinase activity
03
Biological functions
Signal transductionImmune responseT cell activationB cell activationRegulation of Src family kinases
04
Disease associations
ImmunodeficiencyLeukemiaLymphomaAutoimmune diseases
05
Safety considerations
ImmunosuppressionOff-target effects on other hematopoietic cells
06
Interacting drugs
Antibodies (anti-CD45)
1 more in the full profile.
07
Biomarkers
CD45 isoform expression (e.g., CD45RA, CD45RO)CD45 expression levels in leukemia/lymphoma
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