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Protein tyrosine phosphatase receptor type F polypeptide-interacting protein alpha-4 (PPFIA4)
- Target
- PPFIA4
- Molecular classification
- Adaptor protein, Scaffold protein, Protein with sterile alpha motif (SAM) domains, belongs to the liprin-alpha family and acts as a presynaptic assembly protein
01
Overview
Protein tyrosine phosphatase receptor type F polypeptide-interacting protein alpha-4 (PPFIA4), also known as Liprin-alpha-4, is a scaffold/adaptor protein encoded by the PPFIA4 gene. It is a member of the liprin-alpha family, characterized by sterile alpha motif (SAM) domains and coiled-coil structures. PPFIA4 is involved in organizing presynaptic active zones in neurons, regulating cell adhesion dynamics, and facilitating signal transduction by interacting with receptor protein tyrosine phosphatases (especially the LAR-RPTP family). It modulates cellular responses to hypoxia and can affect metabolic pathways (e.g., glycolysis) in cancer cells. Its biological functions are implicated in synapse formation, cancer progression, cardiovascular remodeling, and cellular adaptation to environmental stress, but PPFIA4 is not currently considered a direct therapeutic target[1][4][5][6].
- Other names
- Liprin-alpha-4PTPRF interacting protein alpha 4KIAA0897Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4PTPRF-interacting protein alpha-4Liprin-alpha4
02
Biological functions
Synapse organization (particularly presynaptic assembly)Regulation of cell adhesion (modulates disassembly of focal adhesions and cell-cell adhesion)Signal transduction (links cell surface receptors to intracellular signaling mechanisms)Regulation of glycolysis in cancer cells (metabolic function in the tumor context)
03
Disease associations
Cancer (e.g., regulation of glycolysis, tumor microenvironment, chemoresistance)Cardiovascular disease (early-onset atrial fibrillation, arrhythmogenesis)Neurodevelopment/synaptic disorders (due to its synaptic organization role)
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