Protein tyrosine phosphatase receptor type K (PTPRK)

Protein tyrosine phosphatase receptor type K is a receptor-type protein tyrosine phosphatase with a single transmembrane domain, extracellular regions (including a MAM domain, Ig-like domain, and fibronectin type III-like repeats), and tandem intracellular phosphatase domains. PTPRK is primarily involved in removing phosphate groups from tyrosine residues on proteins, antagonizing tyrosine kinase activity. It is localized at cell junctions, regulates the cadherin-catenin complex, and modulates EGFR and β-catenin pathways, acting as a tumor suppressor by inhibiting cell proliferation and migration. Its expression and activity are regulated by proteolysis, glycosylation, and alternative splicing. Dysregulation or loss of PTPRK has been implicated in multiple cancers and inflammatory diseases, making it a potential therapeutic target and biomarker.

Other names

Receptor-type tyrosine-protein phosphatase kappaPTPRKPTPKProtein-tyrosine phosphatase kappaR-PTP-kappadJ480J14.2.1R-PTP-KAPPAPTPkappa

Drugs (theoretical or experimental) targeting PTPRK would likely function as PTP inhibitors, preventing the dephosphorylation of downstream substrates (such as EGFR and β-catenin). Inhibition would be expected to increase tyrosine phosphorylation signaling, affecting cell proliferation and migration.