Protein tyrosine phosphatase receptor type Q (PTPRQ)

Protein tyrosine phosphatase receptor type Q (PTPRQ) is a member of the type III receptor-like protein tyrosine phosphatase family, consisting of an extracellular region with multiple fibronectin type III domains, a transmembrane helix, and a cytoplasmic phosphatase domain. It is active against phosphatidylinositol phosphates, with limited activity against phosphotyrosine, and plays crucial roles in regulating cellular survival, proliferation, differentiation, and subcellular architecture. PTPRQ is essential for maturation of cochlear hair bundles, thereby having a critical role in auditory function. Mutations in PTPRQ are linked to both autosomal dominant and recessive hearing loss. Additionally, changes in PTPRQ expression and mutations have been implicated in various cancers, suggesting its broader role in pathology and potential as a therapeutic target. PTPRQ also contributes to adipogenesis by regulating PI3K/AKT signaling through dephosphorylation of PIP3.

Other names

Phosphatidylinositol phosphatase PTPRQR-PTP-QReceptor-type tyrosine-protein phosphatase QDFNA73DFNB84DFNB84APTPGMC1Protein-tyrosine phosphatase, receptor-type, expressed by glomerular mesangial cellsDeafness, autosomal recessive 84Deafness, autosomal dominant 73

Dephosphorylation of phosphatidylinositol phosphates (PIP2/PIP3), Modulation of AKT1 phosphorylation and downstream PI3K/AKT signaling