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Target intelligence / Profile preview
Protein Tyrosine Phosphatase Receptor Type S (PTPRS)
- Target
- PTPRS
- Molecular classification
- Receptor, Enzyme, Protein Tyrosine Phosphatase
01
Overview
Protein tyrosine phosphatase receptor type S (PTPRS) is a receptor-type protein tyrosine phosphatase involved in signal transduction by dephosphorylating specific substrates. It plays a critical role in brain development, axon guidance and repair, and cell-cell interactions. High expression is a prognostic marker for cholangiocarcinoma, and PTPRS mimetics show potential for treating spinal cord injuries.
- Other names
- R-PTP-SR-PTP-sigmaPTPσ
02
Mechanism of action
Tyrosine phosphatase; dephosphorylates specific substrates
03
Biological functions
Signal transductionCell growth regulationCell differentiationMitotic cycle progressionBrain developmentAxon guidanceAxon repairCell-cell interaction
04
Disease associations
CancerSpinal cord injuryCholangiocarcinoma
05
Biomarkers
PTPRS expression (cholangiocarcinoma prognosis)
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