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Target intelligence / Profile preview
Protein Tyrosine Phosphatase Receptor Type Z1 (PTPRZ1)
- Target
- PTPRZ1
- Molecular classification
- Receptor, Enzyme, Receptor-type Protein Tyrosine Phosphatase
01
Overview
Protein Tyrosine Phosphatase Receptor Type Z1 (PTPRZ1) is an enzyme that functions as a single-pass type I membrane protein. It is primarily expressed in the central nervous system and plays a role in oligodendrocyte precursor proliferation and signal transduction. Altered expression of PTPRZ1 is associated with several pathological conditions, including cancer and neurological disorders, suggesting its potential as a biomarker and therapeutic target.
- Other names
- HPTPZHPTPzetaPTP-ZETAPTP18PTPRZPTPZR-PTP-zeta-2RPTPBRPTPbetaPhosphacan
02
Mechanism of action
Modulation of downstream signaling pathways through ligand binding or pharmacological agents, affecting cellular processes such as proliferation and differentiation.
03
Biological functions
Signal transductionCell proliferationCell differentiationRegulation of oligodendrocyte precursor proliferationDephosphorylation of tyrosine residues
04
Disease associations
CancerNeurological DisordersGlioblastomaGastric CancerMultiple SclerosisHypoxia
05
Biomarkers
PTPRZ1 expression levels in glioblastoma cellsPTPRZ1 expression levels in gastric cancer cells
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