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Target intelligence / Profile preview
Protein unc-119 homolog B (UNC119B)
- Target
- UNC119B
- Molecular classification
- Lipid binding chaperone/cofactor, Immunoglobulin-like β-sandwich fold protein, Protein trafficking factor (for myristoylated proteins), Other (not a receptor, ion channel, enzyme, transporter, or transcription factor)
01
Overview
Protein unc-119 homolog B (UNC119B) is a lipid-binding trafficking chaperone that accommodates and solubilizes N-myristoylated proteins, preventing their inappropriate localization and facilitating their directed transport within the cell. UNC119B contains an immunoglobulin-like β-sandwich fold which generates a hydrophobic pocket, allowing it to bind the myristoyl moiety of specific cargo proteins. Two classes of cargoes are distinguished by their affinity for UNC119B, and release is regulated by small GTPases such as ARL2 and ARL3. UNC119B exhibits nuanced specificity compared to its paralog UNC119A, including unique sequence features and alternative structural conformations which influence cargo protein binding and release. Its trafficking activity enables delivery of signaling proteins to the primary cilium and immunological synapse, making it essential for spatial regulation of membrane-associated proteins in various cell types, including photoreceptors, sensory neurons, and immune cells
- Other names
- UNC119BMGC5139POC7BPOC7 centriolar protein homolog BUnc-119 homolog BProtein unc-119 homolog B
02
Mechanism of action
Not applicable; UNC119B is not a direct drug target in current therapeutic strategies. Its function is protein-protein interaction based
03
Biological functions
Facilitates trafficking of N-myristoylated proteins between cellular membrane compartments by masking their hydrophobic moietyCargo sorting to primary cilium and immunological synapseCellular protein localizationRegulation of signaling hubs via localization of key signaling proteins
04
Disease associations
Nephronophthisis — trafficking of nephrocystin-3 to ciliaPotential indirect roles in immune function and signal transduction relevant to T-cell activationOther (roles emerging in ciliary function and diseases of trafficking)
05
Safety considerations
None established in current literature; therapeutic targeting challenges may relate to broad trafficking roles and potential for off-target effects in key cellular compartments if manipulated
06
Interacting drugs
None identified; no approved or experimental drugs directly target UNC119B as of current literature
07
Biomarkers
None reported; UNC119B is not used in clinical biomarker panels for patient selection or efficacy monitoring
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