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Protein unc-45 homolog B (UNC45B)
- Target
- UNC45B
- Molecular classification
- Other (Myosin-specific molecular chaperone, UCS domain protein), Co-chaperone (interacts with Hsp90 and Hsp70)
01
Overview
Protein unc-45 homolog B (UNC45B) is a myosin-specific molecular chaperone highly expressed in striated muscle. UNC45B ensures proper folding and assembly of myosin II, coordinating the formation of contractile sarcomeres essential for muscle function. Structurally, it comprises an N-terminal tetratricopeptide repeat (TPR) domain for binding co-chaperones (Hsp90, Hsp70), a central region of unclear function, and a C-terminal UCS domain directly involved in myosin binding. UNC45B’s chaperone activity is required for both muscle development and stress-induced maintenance of myosin function. Mutations or altered localization are linked to diseases that include progressive myopathy (muscle weakness) and congenital cataracts. Although UNC45B is crucial for biologically relevant processes, it is not a classical therapeutic target, and no drugs are known to directly interact with it.
- Other names
- UNC45BUnc-45BCMYA4SMUNC45CTRCT43MFM11UNC45UNC-45Bprotein unc-45 homolog Bcardiomyopathy associated 4striated muscle UNC45unc-45 homolog B
02
Mechanism of action
None (no drugs are known to specifically target or act upon UNC45B)
03
Biological functions
Myosin folding and assemblySarcomere organizationMuscle contractility and myofibrillogenesisMaintenance of muscle function during cellular stressLens development
04
Disease associations
Progressive myopathy (muscle weakness; pathogenic variants lead to progressive muscle diseases)Congenital cataract (mutations can cause developmental cataracts)Cardiomyopathy (impaired myofibrillar organization affects cardiac muscle)
05
Safety considerations
Loss-of-function or pathogenic variants result in severe muscle weakness and myopathiesAltered expression implicated in cardiac and skeletal muscle dysfunction, but no therapeutic interventions targeting this pathway have established safety risks in humans
06
Biomarkers
Mutations in UNC45B gene may serve as biomarkers for certain forms of myopathy or congenital cataractProtein expression levels or localization may be used for research in muscle-related pathologies
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