Protein yippee-like 5 (YPEL5)

Protein yippee-like 5 (YPEL5) is a highly conserved eukaryotic protein and the fifth member of the YPEL family, predicted to contain a zinc finger motif. YPEL5 localizes to the nucleus and centrosome in interphase, then redistributes to spindle poles and spindle midzone throughout mitosis and cytokinesis. It is a key mediator of cell cycle progression, proliferation, and apoptosis, functioning as a component of the CTLH E3 ubiquitin-protein ligase complex to promote degradation of transcription factors such as HBP1. YPEL5 interacts with RanBPM and RanBP10, and in mammals, it acts as a negative regulator of interferon-beta signaling by binding TBK1/IKBKE kinases. Knockdown or loss of YPEL5 disrupts cell division and embryonic development, causing hepatomegaly and lethality in knockout zebrafish, and impairs immune response. In cancer, especially colorectal and hematological malignancies, aberrant YPEL5 expression drives cell proliferation and is subject to epigenetic suppression via the m6A methyltransferase pathway. Overall, YPEL5 is primarily classified as a cell cycle and ubiquitin pathway regulator, with roles in proliferation, apoptosis, immune signaling, and tumor suppression.

Other names

Yippee like 5YPEL5CGI-127Protein yippee-like 5Ypel5yippee protein homologYippee-like 5 (Drosophila)2310076K21Rik