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Protein ZAR1-like (ZAR1L)
- Target
- ZAR1L
- Molecular classification
- RNA-binding protein, mRNA-binding protein, Zinc finger protein
01
Overview
Protein ZAR1-like (ZAR1L) is a member of the ZAR1 family of proteins and is predominantly expressed in oocytes and early embryos. It plays a crucial role as an mRNA-binding protein required for maternal mRNA storage, translation, and degradation during oocyte maturation. ZAR1L is believed to regulate the formation of phase-separated membraneless compartments that sequester maternal mRNAs and modulate their translation by binding to 3'-UTR regions, thereby preventing premature translation during early embryonic cell cycles. Mutations in ZAR1L have been associated with certain developmental disorders, but it is not documented as a pharmacological or therapeutic target[2][5][8].
- Other names
- ZAR1LZygote arrest protein 1-likeZAR2Z3CXXC7Zinc finger, 3CxxC-type 7
02
Biological functions
Maternal mRNA storageRegulation of mRNA translationRegulation of mRNA degradation during oocyte maturationEarly embryonic development
03
Disease associations
Arthrogryposis, distal, type 1C (possible association)Mullerian aplasia and hyperandrogenism (possible association)Other developmental disorders (limited evidence; functions inferred from orthologs)
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