Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Proteinase 3 (PR3)
- Target
- PR3
- Molecular classification
- Serine protease, Enzyme
01
Overview
Proteinase 3 (PR3), also known as PRTN3, is a serine protease enzyme primarily expressed in neutrophil granulocytes. It plays a key role in innate immunity, degrades extracellular matrix proteins, and activates inflammatory cytokines. Clinically, it is known as the primary autoantigen targeted by anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA subtype, highly associated with granulomatosis with polyangiitis (GPA) and other vasculitides. It acts both intracellularly—regulating proliferation or apoptosis—and at cell membranes where its expression correlates with chronic inflammatory risk.
- Other names
- PRTN3PRTN-3Myeloblastin
02
Mechanism of action
Proteolytic activity; Modulation of inflammation
03
Biological functions
Innate immunityAntimicrobial peptide generationExtracellular matrix degradationImmune regulationCytokine activationMyeloid differentiation
04
Disease associations
Granulomatosis with polyangiitis (GPA)Microscopic polyangiitisEosinophilic granulomatosis with polyangiitisVasculitisRheumatoid arthritisInflammatory bowel disease (IBD)Type 2 diabetesCardiovascular diseasesAtherosclerosisAutoimmune conditions
05
Safety considerations
Unregulated proteolytic activityVascular damage due to ANCA activation of neutrophilsPotential for increased inflammation
06
Interacting drugs
Alpha1-antitrypsin (α1AT)
07
Biomarkers
c-ANCAPR3-specific ANCAs
Beyond the preview
Go deeper on Proteinase 3 (PR3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Proteinase 3 (PR3).